Parasym’s neuromodulation technology was revealed to significantly decrease Postural Orthostatic Tachycardia Syndrome (POTS) at a clinical trial presentation at the Heart Rhythm Society 2023. The groundbreaking study shows the potential for a safe and effective treatment to support the estimated 16 million people living with the condition.
POTS is a condition characterised by an abnormal increase in heart rate upon standing. The condition has debilitating symptoms including anxiety, insomnia, chronic fatigue, weakness, headaches and brain fog. Reports also suggest that 14% of long covid sufferers may develop POTS. It is the most prevalent form of dysautonomia in young people and is associated with significant morbidity and poor quality of life.
The presented randomised-controlled trial, led by principal investigator Dr Stavros Stavrakis at the University of Oklahoma’s Health Sciences Centre, used the Parasym neuromodulation system to test the clinical efficacy of targeted non-invasive vagal neuromodulation in POTS.
By sending targeted electrical signals, the Parasym system has been proven to restore autonomic balance and reduce systemic inflammation within patients. The device works by non-invasively modulating the vagus nerve via a wearable worn on the ear and has been demonstrated in multiple mechanistic and clinical studies to favourably alter the autonomic and immune systems.
Dr Elisabetta Burchi MD, MBA, Head of Translation Research at Parasym, said: “This study, along with our other research, shows once more, the potential of non-invasive neuromodulation, both as a mechanistic tool to better elucidate the pathophysiology underpinning complex diseases and as a new, safe treatment approach. The capability of non-invasively modulating the autonomic nervous system allows us to produce multi-systemic effects that can be leveraged for the treatment of a range of different clinical conditions and populations.”
One of Parasym’s patients, Connie, from Oxfordshire, added: “I’ve struggled with Lyme disease, autonomic issues, EBV, pituitary problems including adrenal insufficiency, fatigue, insomnia and gastrointestinal issues. It was very serious, in and out of hospitals, I needed a wheelchair and was practically bed bound for several years. Many days I couldn’t even lift my head off the pillow due to my fatigue and Postural Tachycardia Syndrome. I’ve seen so many doctors and taken so many different medications and supplements. With the Parasym I now have a tool I can use myself at home which doesn’t have the nasty side effects medications do.”
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